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                <text>Temas oftalmológicos en la práctica diaria / Honorio Campuzano</text>
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                <text>114, [3] p. : fots. col., dibs. ; 23 cm.</text>
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                <text>Bibliografía: p.[115-117]</text>
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                <text>Manuales</text>
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                <text>Asunción : Editorial de la Facultad de ciencias médicas (EFACIM),</text>
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                <text>Perlas y consejos: Técnica de Canabrava [Fijación de lente intraocular instraescleral].</text>
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                <text>El manejo de la afaquia ha sido durante mucho tiempo un obstáculo para los cirujanos de segmento anterior. Tras la aparición de los implantes secundarios con fijación escleral, en la década de los ochenta, inicialmente descritos por el Dr. Enrique S. Malbran, se desarrollaron y perfeccionaron numerosas técnicas quirúrgicas en busca de mejores resultados. En este trabajo, analizaremos los principales consejos para utilizar con el lente intraocular de 4 ojales. Los puntos principales que se discutirán serán: túnel largo, aguja correcta, tamaño y entierro del flanged.</text>
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                <text>SaoXpress, marzo de 2021, año 3, nro. 7, p. 30-32.</text>
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                <text>El documento archivado en biblioteca sólo tiene la sección 11 dedicada a la visión.</text>
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                <text>Automóviles</text>
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                <text>Examen de aptitud para la conducción de vehículos</text>
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                <text>El documento archivado en biblioteca sólo tiene la sección 11 dedicada a la visión.</text>
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                <text>Vision standars for driving in Canada /  Can. Ophthalmol. Soc.|245h|[recurso electrónico].</text>
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            <name>Date Created</name>
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                <text>2000.</text>
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                <text>Documento extraído del sitio http://www.eyesite.ca/english/program-and-services/policy-statements-guidelines/drivingstd.html.</text>
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                <text>Automóviles</text>
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                <text>Fotocoagulación con láser verde de argón frente a láser rojo de criptón para la neovascularización coroidea extrafoveal : resultados a un año en la histoplasmosis ocular / The Canadian ophthalmology study group</text>
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            <description>Date of creation of the resource.</description>
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                <text>Archives of Ophthalmology. Edición Española; Barcelona, ene.-feb.1995. ISSN: 1130-5134</text>
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                <text>Vol. 6, 1 (1995), p.12-20Título: Archives of Ophthalmology. Edición Española</text>
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                <text>Neovascularización coroidea</text>
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                <text>Histoplasmosis ocular</text>
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                <text>Urgencias oftalmológicas en atención primaria</text>
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                <text>Costa-Vila, J.</text>
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                <text>Canals-Imhor, M.</text>
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                <text>Pita-Salorio, D.</text>
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                <text>Las urgencias oftalmológicas constituyen alrededor del 11 a 12% del total de urgencias asistidas en un hospital. Pacientes con orzuelos, conjuntivitis agudas, dacriocistitis, cuerpos extraños corneales y accidentes son los problemas más comunes.</text>
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                <text>Urgencias oftalmológicas</text>
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En los últimos años, estudiamos las propiedades regenerativas, anti-inflamatorias e inmuno-moduladoras de las vesículas extracelulares (EVs) secretadas por células madre mesenquimales (MSCs). Debido a que los procesos que conllevan a la opacidad corneal se deben básicamente a una desregulación de mecanismos regenerativos e inflamatorios, en el presente trabajo, nos propusimos evaluar el potencial terapéutico de las EVs derivadas de MSCs en un modelo experimental de injuria corneal.&#13;
&#13;
Métodos&#13;
&#13;
Previamente, desarrollamos un sistema de aislamiento de vesículas extracelulares y posterior análisis de su potencial anti-inflamatorio (in vitro). Este sistema de producción y aislamiento de EVs comprendido por: cultivo controlado de MSCs (de cordón umbilical humano), recolección de medio condicionado y purificación de EVs mediante cromatografía de intercambio iónico. En este estudio, pusimos a punto un modelo murino de regeneración corneal mediante aplicación tópica de 10ul de NaOH (0,125 M) y posterior tratamiento con igual volumen de EVs (1x109 partículas/ml) por 5 días consecutivos. La acción terapéutica de las EVs se evaluó mediante tinción tisular (hematoxilina-eosina) y determinación de los niveles de expresión de citoquinas inflamatorias  por real-time RT-PCR.&#13;
&#13;
Resultados&#13;
&#13;
Tanto en la observación clínica, como en la tisular, se observa  que el NaOH indujo injuria moderada del tejido corneal con un claro restablecimiento del tejido luego del tratamiento con vesículas (vs vehículo). Respecto a las citoquinas evaluadas, estas aumentaron significativamente su expresión luego de la injuria química y descendieron fuertemente tras el tratamiento con EVs (n=5, p&lt;0.05).&#13;
&#13;
Conclusión&#13;
&#13;
De los resultados obtenidos, se desprende, que  logramos establecer un modelo sencillo de injuria del epitelio corneal en el cual testear diversas estrategias terapéuticas y, a su vez, demostramos  el enorme potencial regenerativo de las EVs en patologías oculares de orden inflamatorio.</text>
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