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                <text>Uveítis anterior granulomatosa bilateral como efecto adverso a brimonidina tópica&#13;
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                <text>Caffarelli, Natalia </text>
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                <text>Objetivo: Presentación de un caso de uveítis anterior granulomatosa bilateral secundaria a tratamiento con brimonidina tópica 0,2%.&#13;
&#13;
Caso Clínico: Paciente masculino de 63 años con antecedente de glaucoma en ambos ojos, en tratamiento tópico con brimonidina desde hace 15 meses, concurre al servicio de oftalmología por ojo rojo, sensación de cuerpo extraño y fotofobia de 10 días de evolución.&#13;
&#13;
Al examen físico su agudeza visual (AV) era de 8/10 en ojo derecho (OD) y 10/10 en ojo izquierdo (OI) mejor corregida. A la biomicroscopia presentaba edema e hiperemia en borde palpebral, intensa hiperemia conjuntival, reacción papilar en conjuntiva tarsal inferior, reacción en cámara anterior positiva, y precipitados retroqueráticos granulomatosos en ambos ojos. La presión intraocular medida con tonómetro de Goldman resultó en 14 mmHg para ojo derecho (OD) y 15 mmHg para ojo izquierdo (OI). El examen de fondo de ojos (FO) resultó sin particularidades en ambos ojos.&#13;
&#13;
Se solicitó una serie de estudios complementarios para descartar otras causas de uveítis, resultando todos dentro de parámetros normales.&#13;
&#13;
Se planteó el diagnóstico de uveítis anterior granulomatosa bilateral secundaria a brimonidina tópica y se indica reemplazo de colirio antiglaucomatoso y tratamiento con esteroides tópicos suaves, con respuesta favorable y resolución completa del cuadro.&#13;
&#13;
Conclusión: En el caso presentado, la uveítis anterior granulomatosa bilateral se resolvió por completo tras la suspensión de la brimonidina y la administración de tratamiento tópico antiinflamatorio, confirmando la relación causal con el fármaco.</text>
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                <text>Consejo Argentino de Oftalmología</text>
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                <text>Oftalmología Clínica y Experimental, vol. 18, nro. 3, sep. de 2025, p. 268-374</text>
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                <text>Melanocitoma epitelioide pigmentado conjuntival: a propósito de un caso</text>
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                <text>Objetivo: Presentar un caso clínico de melanocitoma epitelioide pigmentado conjuntival y su manejo terapéutico mediante cirugía y mitomicina C tópica.&#13;
&#13;
Caso clínico: Paciente femenina de 65 años consultó por crecimiento acelerado de una lesión sólida preexistente en ojo derecho. Presentaba una lesión pigmentada en conjuntiva que invadía el área corneal de 7,5 mm. Tras realizar una evaluación mediante ultrabiomicroscopía, se procedió a su biopsia escisional (técnica no-touch) y cuatro ciclos de tratamiento posoperatorio con mitomicina C al 0,04% cada 6 horas durante 7 días con una semana de intervalo de descanso. El diagnóstico histopatológico e inmunohistoquímico confirmó un melanocitoma epitelioide pigmentado (condición extremadamente infrecuente en la conjuntiva ocular) con pocos casos reportados previamente en la literatura. A los 5 meses de seguimiento oftalmológico y oncológico, la paciente no tuvo recidivas, su visión se encuentra conservada y se mantiene un seguimiento cercano.&#13;
&#13;
Conclusión: Se describe un caso poco frecuente de melanocitoma epitelioide pigmentado conjuntival que pudo ser tratado y controlado de manera local. Serán necesarios más casos para considerar la utilidad de coadyuvantes como la mitomicina C tópica.</text>
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                <text>Oftalmología Clínica y Experimental, vol. 18, nro. 1, mar. de 2025, p. 120-122</text>
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                <text>Archivos Argentinos de Oftalmología, diciembre de 2016, n° 7, p. 55-8.</text>
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