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                <text>Purpose. To discuss the scientific facts and controversies surrounding human retinal transplantation. Methods. In January 1995, we began multicenter, phase I clinical studies to assess the safety of transplanting neural retina into the subretinal space of patients with advanced retinal degenerative disease. A total of 18 patients with retinitis pigmentosa and one patient with age-related macular degeneration were transplanted with a suspension of fetal neural retina (14 to 18 weeks gestational age). No patients received systemic immunosuppression. Patients underwent pre-operative and post-operative visual testing, that in the most recent cases included a newly developed test battery for low level vision, assessment of accurate projection of rays, visual acuity, ERG, and visual fields. Results. The longest follow-up to date has been 2.5 years on four patients. No evidence of inflammation, infection, overt rejection or compromise to the host eye was noted in any patients. There was one case of retinal detachment. In this patient, vision worsened from hand motion to light perception. Three patients showed a 4 to 10 fold increase in light sensitivity starting one to two months after transplantation. Two of these patients have since returned to their pre-operative baseline. Six patients have shown improvement in vision starting 4 to 6 months post-transplantation which has been sustained to date. Two of these patients developed the ability to undergo visual field testing. Conclusions. Safe and efficient delivery of neural retinal cells into the subretinal space of patients with advanced retinitis pigmentosa has been achieved. The results warrant further studies to quantify the possible benefits of neural retinal transplantation in patients suffering from retinal degenerative diseases. A variety of issues regarding human retinal transplantation is discussed.</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13133">
                <text>Human neural retinal transplants into retinitis pigmentosa: facts and controversy / Manuel del Cerro, David A. DiLoreto, Constancia del Cerro, Eliot S. Lazar</text>
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          </element>
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            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13134">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13135">
                <text>Vol. 4, 3Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13136">
                <text>Degeneración macular relacionada con la edad</text>
              </elementText>
              <elementText elementTextId="13137">
                <text>Retina</text>
              </elementText>
              <elementText elementTextId="13138">
                <text>Retinitis pigmentosa</text>
              </elementText>
              <elementText elementTextId="13139">
                <text>Retina</text>
              </elementText>
              <elementText elementTextId="13140">
                <text>Células fetales</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13141">
                <text>Del Cerro, Manuel</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13142">
                <text>Boston : 1998</text>
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            </elementTextContainer>
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          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13143">
                <text>Di Loreto, David A.</text>
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              <elementText elementTextId="13144">
                <text>Del Cerro, Constancia</text>
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              <elementText elementTextId="13145">
                <text>Lazar, Eliot S. L.</text>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13146">
                <text>eng</text>
              </elementText>
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          </element>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13122">
                <text>RPE and photoreceptor transplantation / Gouras P., Algvere P. V</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="70">
            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13123">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13124">
                <text>Vol. 4, 3Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13125">
                <text>Transplante de epitelio pigmentario</text>
              </elementText>
              <elementText elementTextId="13126">
                <text>Retina</text>
              </elementText>
              <elementText elementTextId="13127">
                <text>Experimental</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13128">
                <text>Gouras, P.</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13129">
                <text>Boston : 1998</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13130">
                <text>Algvere, P. V.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13131">
                <text>eng</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
  <item itemId="1066" public="1" featured="0">
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13112">
                <text>Symptomatic visual loss from an optic tract lesion in multiple sclerosis[a 25 year old man with an acute decrease in vision] / Yichieh Shiuey</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="70">
            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13113">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13114">
                <text>Vol. 4, 3Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13115">
                <text>Esclerosis múltiple</text>
              </elementText>
              <elementText elementTextId="13116">
                <text>Enfermedades sistémicas</text>
              </elementText>
              <elementText elementTextId="13117">
                <text>Nervio óptico</text>
              </elementText>
              <elementText elementTextId="13118">
                <text>Neuroftalmología</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13119">
                <text>Shiuey, Yichieh</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13120">
                <text>Boston : 1998</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13121">
                <text>eng</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
  <item itemId="1065" public="1" featured="0">
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13103">
                <text>Hemifield slide phenomenon [A 31 year old woman with vertical diplopia for 2 months] / Kenneth Graham</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="70">
            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13104">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13105">
                <text>Vol. 4, 3Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13106">
                <text>Diplopia</text>
              </elementText>
              <elementText elementTextId="13107">
                <text>Campo visual</text>
              </elementText>
              <elementText elementTextId="13108">
                <text>Estrabismo</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13109">
                <text>Graham, Kenneth</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13110">
                <text>Boston : 1998</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13111">
                <text>eng</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
  <item itemId="1064" public="1" featured="0">
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13092">
                <text>Posterior scleritis with choroidal detachment and angle closure glaucoma  [a 49 year old man with 6 months of swelling around the right eye] / Jay C. Rudd</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="70">
            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13093">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13094">
                <text>Vol. 4, 3Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13095">
                <text>Escleritis</text>
              </elementText>
              <elementText elementTextId="13096">
                <text>Escleritis posterior</text>
              </elementText>
              <elementText elementTextId="13097">
                <text>Glaucoma</text>
              </elementText>
              <elementText elementTextId="13098">
                <text>Desprendimiento de coroides</text>
              </elementText>
              <elementText elementTextId="13099">
                <text>Presión intraocular</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13100">
                <text>Rudd, Jay C.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13101">
                <text>Boston : 1998</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13102">
                <text>eng</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
  </item>
  <item itemId="1063" public="1" featured="0">
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13076">
                <text>Phenotypic variations in x-linked retinitis pigmentosa / Andréasson S., Ponjavic V., Abrahamson M., Ehinger B., Wu W., Fujita R., Buraczynska M., Swaroop A</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="70">
            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13077">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13078">
                <text>Vol. 4, 4Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13079">
                <text>Retinitis pigmentosa</text>
              </elementText>
              <elementText elementTextId="13080">
                <text>Genética</text>
              </elementText>
              <elementText elementTextId="13081">
                <text>Retina</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13082">
                <text>Andréasson, S.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13083">
                <text>Boston : 1998</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13084">
                <text>Ponjavic, V.</text>
              </elementText>
              <elementText elementTextId="13085">
                <text>Abrahamson, M.</text>
              </elementText>
              <elementText elementTextId="13086">
                <text>Ehinger, B.</text>
              </elementText>
              <elementText elementTextId="13087">
                <text>Wu, W.</text>
              </elementText>
              <elementText elementTextId="13088">
                <text>Fujita, R.</text>
              </elementText>
              <elementText elementTextId="13089">
                <text>Buraczynska, M.</text>
              </elementText>
              <elementText elementTextId="13090">
                <text>Swaroop, A.</text>
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            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13091">
                <text>eng</text>
              </elementText>
            </elementTextContainer>
          </element>
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  </item>
  <item itemId="1062" public="1" featured="0">
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13066">
                <text>Photoreceptor degeneration in a selected animal model: the Abyssinian cat / K. Narfstrom</text>
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          </element>
          <element elementId="70">
            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13067">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13068">
                <text>Vol. 4, 4Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13069">
                <text>Retina</text>
              </elementText>
              <elementText elementTextId="13070">
                <text>Fotoreceptores</text>
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              <elementText elementTextId="13071">
                <text>Herencia</text>
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              <elementText elementTextId="13072">
                <text>Experimental</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13073">
                <text>Narfstrom, K.</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13074">
                <text>Boston : 1998</text>
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            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13075">
                <text>eng</text>
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          </element>
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  <item itemId="1061" public="1" featured="0">
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13057">
                <text>Central serous chorioretinopathy [43-year-old man presents with blurry vision of the right eye] / Balamurali K. Ambati</text>
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            </elementTextContainer>
          </element>
          <element elementId="70">
            <name>Is Part Of</name>
            <description>A related resource in which the described resource is physically or logically included.</description>
            <elementTextContainer>
              <elementText elementTextId="13058">
                <text>Digital Journal of Ophthalmology; Boston, 1998</text>
              </elementText>
              <elementText elementTextId="13059">
                <text>Vol. 4, 4Título: Digital Journal of Ophthalmology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13060">
                <text>Retinopatía central serosa</text>
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              <elementText elementTextId="13061">
                <text>Corioretinopatía central serosa</text>
              </elementText>
              <elementText elementTextId="13062">
                <text>Retina</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13063">
                <text>Ambati, Balamurali K.</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13064">
                <text>Boston : 1998</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13065">
                <text>eng</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
