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                <text>En los últimos 70 años la medicina ha tomado paulatinamente al método científico como su guía principal, lo que conocemos como medicina basada en la evidencia. La eficacia y seguridad de un tratamiento médico debe ser probado por un estudio clínico. Se presentan en este artículo las diferentes variedades de los estudios clínicos en medicina, sus ventajas y sus desventajas.</text>
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                <text>SaoXPress, noviembre de 2019, vol. 3, Año 1, p. 17-20.</text>
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                <text>Los estudios pivotales MARINA y ANCHOR  para el ranibizumab y VIEW1 y VIEW2 para el aflibercept demostraron la eficacia y seguridad de ambas drogas para el tratamiento de la degeneración macular asociada con la edad de tipo neovascular. El intervalo de aplicación en ambos estudios era fijo cada 4 semanas para el ranibizumab y cada 8 semanas para el aflibercept luego de las primeras 3 dosis mensuales (dosis de carga). Estos regímenes de tratamiento resultan una gran carga para los pacientes y los sistemas de salud por lo que se exploraron diferentes estrategias para disminuir la cantidad de inyecciones y visitas a los centros de salud.</text>
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                <text>vol. 78, n. 2 (abril-julio 2005), p. 271-274Título: Archivos de Oftalmología de Buenos Aires</text>
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